产品货号：
Z37155
中文名称：
JAK2抗体
英文名称：
Anti-JAK2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-JAK2 Antibody |
| 指标别名 | Janus kinase 2;JTK10;JAK2 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF |
| 基因名称 | JAK2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human JAK2 Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription.For example,cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation,activation,and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain.Then,STAT5 (STAT5A or STAT5B) is recruited,phosphorylated and activated by JAK2. |
| 实际分子量 | 131KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Janus kinase 2,commanly called JAK2,is a human protein that has been implicated in signaling by members of the type II cytokine receptor family,the GM-CSF receptor family,the gp130 receptor family,and the single chain receptors.Exactly,JAK2 kinase is a member of a family of tyrosine kinases involved in cytokine receptor signaling.The JAK2 gene is mapped to 9p24.1.The JAK2 gene encodes a 1,132-amino acid protein that shares 95% sequence similarity to rat and pig Jak2.JAK2 is constitutively associated with the prolactin receptor and that it is activated and tyrosine phosphorylated upon PRL binding to the PRL receptor.JAK2,and more specifically just its intact N-terminal domain,binds to EPOR in the endoplasmic reticulum and promotes its cell surface expression.The human JAK2 is present in the nucleus of hematopoietic cells and directly phosphorylates tyr41 on histone H3. |
| Uniprot ID | O60674 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 |
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